ZC3H7A

Across TCGA patient cohorts, ZC3H7A mutation is significantly associated with the RNA expression of many other genes, with 2,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H7A-associated genes across cancer lineages are WDR5, FAM168B, and FANCC. Each is linked with ZC3H7A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H7A-to-partner and partner-to-ZC3H7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR5 grouped by ZC3H7A-low versus ZC3H7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H7A→partner) and Y-score (partner→ZC3H7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR5 →	+0.417	+2.524	<.001	<.001	3	3
UCEC	FAM168B →	+0.447	+2.592	.003	<.001	3	3
UCEC	FANCC →	+0.336	+1.893	.004	<.001	3	3
UCEC	PDXK →	+0.369	+1.805	.007	.007	3	3
UCEC	ZNF367 →	+0.599	+1.947	<.001	.002	3	3
UCEC	DIS3L →	+0.362	+2.447	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,209 associations by consensus.

WDR5 by ZC3H7A expression — UCEC

Explore this box plot interactively →