ZC3H7A

Across TCGA patient cohorts, ZC3H7A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H7A-associated genes across cancer lineages are 14-3-3_beta, MEK1, and PDCD4. Each is linked with ZC3H7A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H7A-to-partner and partner-to-ZC3H7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZC3H7A-low versus ZC3H7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H7A→partner) and Y-score (partner→ZC3H7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.072	-1.973	.036	.029	3	2
UCEC	MEK1 →	+0.304	+2.247	.014	.001	3	2
UCEC	PDCD4 →	-0.429	-1.700	.007	.040	3	2
UCEC	Rab11 →	-0.112	-1.514	.023	.015	3	2
UCEC	Rab25 →	-0.376	-2.137	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.242	-2.415	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

14-3-3_beta by ZC3H7A expression — UCEC

Explore this box plot interactively →