ZC3H7A

Across TCGA cell cohorts, ZC3H7A mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H7A-associated genes across cancer lineages are TFAP2D, CSH1, and GAGE12J. Each is linked with ZC3H7A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H7A-to-partner and partner-to-ZC3H7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFAP2D grouped by ZC3H7A-low versus ZC3H7A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H7A→partner) and Y-score (partner→ZC3H7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	2
PANCREAS	CSH1 →	+0.073	+5.139	<.001	<.001	3	1
PANCREAS	GAGE12J →	+0.047	+4.614	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
CNS	CFC1 →	+0.091	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

TFAP2D by ZC3H7A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →