ZC3H4

Across TCGA patient cohorts, ZC3H4 mutation is significantly associated with the RNA expression of many other genes, with 5,431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H4-associated genes across cancer lineages are IER3IP1, TYMS, and TIMM21. Each is linked with ZC3H4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZC3H4-to-partner and partner-to-ZC3H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IER3IP1 grouped by ZC3H4-low versus ZC3H4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H4→partner) and Y-score (partner→ZC3H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IER3IP1 →	+0.499	+3.419	.003	.004	3	5
COAD	TYMS →	+0.616	+3.459	.005	.005	3	4
UCEC	TIMM21 →	+0.463	+1.776	<.001	<.001	3	4
ESCA	ELOAP1 →	+0.340	+4.159	<.001	.009	3	4
LUSC	RNU6-202P →	+0.400	+3.684	<.001	.009	3	4
UCEC	ADNP2 →	+0.550	+2.280	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,431 associations by consensus.

IER3IP1 by ZC3H4 expression — COAD

Explore this box plot interactively →