ZC3H18

Across TCGA pan-cancer cohorts, ZC3H18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZC3H18 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZC3H18 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3H18 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where ZC3H18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.575	0.903	.002	39	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.859	.034	12	view →
LUAD	OS	Quartile	III,IV	0.925	0.358	.021	10	view →
PDAC	OS	Median	IV	0.540	0.951	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZC3H18–HNSC (DFS)

Open the HNSC breakdown →