ZC3H18

Across TCGA patient cohorts, ZC3H18 RNA expression is significantly associated with the mutation status of many other genes, with 13,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H18-associated genes across cancer lineages are TP53, TTN, and ZNF536. Each is linked with ZC3H18 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZC3H18-to-partner and partner-to-ZC3H18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by ZC3H18-low versus ZC3H18-high in GBM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H18→partner) and Y-score (partner→ZC3H18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TP53 →	+2.129	+0.386	<.001	<.001	3	9
READ	TTN →	+1.657	+0.261	<.001	.001	3	6
READ	ZNF536 →	+3.349	+0.425	.003	.002	3	6
READ	RYR2 →	+2.557	+0.298	<.001	.009	3	4
LUAD	PXDN →	+3.205	+0.386	.009	.002	3	4
LUAD	MED12 →	+2.735	+0.344	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,020 associations by consensus.

TP53 by ZC3H18 expression — GBM

Explore this box plot interactively →