ZC3H18

Across TCGA patient cohorts, ZC3H18 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H18-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with ZC3H18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H18-to-partner and partner-to-ZC3H18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZC3H18-low versus ZC3H18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H18→partner) and Y-score (partner→ZC3H18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.162	-1.050	.019	.023	3	2
UCEC	eIF4E →	+0.132	+1.428	.023	.025	3	2
UCEC	ERK2 →	+0.108	+1.584	.042	.004	3	2
UCEC	MSH2 →	-0.160	-1.488	.011	.012	3	2
UCEC	MSH6 →	-0.205	-1.415	.024	.040	3	2
UCEC	PDCD4 →	-0.511	-1.883	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by ZC3H18 expression — UCEC

Explore this box plot interactively →