ZC3H14

Across TCGA patient cohorts, ZC3H14 protein abundance is significantly associated with the RNA expression of many other genes, with 19,261 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZC3H14-associated genes across cancer lineages are VRK1, DLST, and MTHFD1. Each is linked with ZC3H14 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZC3H14-to-partner and partner-to-ZC3H14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZC3H14 versus VRK1 in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H14→partner) and Y-score (partner→ZC3H14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VRK1 →	+1.039	+0.186	<.001	<.001	3	9
HNSC	DLST →	+0.616	+0.157	.003	.001	3	9
HNSC	MTHFD1 →	+0.515	+0.128	<.001	<.001	3	8
UCEC	DNAAF2 →	+0.655	+0.142	.001	.002	3	8
LSCC	L2HGDH →	+0.631	+0.202	<.001	<.001	3	8
HNSC	SUPT16H →	+0.611	+0.158	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,261 associations by consensus.

ZC3H14 vs VRK1 — HNSC

Explore this scatter interactively →