ZC3H12C

Across TCGA pan-cancer cohorts, ZC3H12C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZC3H12C data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZC3H12C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZC3H12C expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where ZC3H12C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.801	0.393	<.001	83	view →
HNSC	OS	Median	III,IV	1.000	0.526	.005	23	view →
LUAD	DFS	Quartile	All	0.780	1.000	.036	4	view →
LSCC	DFS	Median	All	0.977	0.898	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZC3H12C–CCRCC (DFS)

Open the CCRCC breakdown →