ZC3H12C

Across TCGA patient cohorts, ZC3H12C mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H12C-associated genes across cancer lineages are MEK1, C-Raf, and Notch1. Each is linked with ZC3H12C in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H12C-to-partner and partner-to-ZC3H12C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZC3H12C-low versus ZC3H12C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12C→partner) and Y-score (partner→ZC3H12C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.450	+2.222	<.001	<.001	3	3
COAD	C-Raf →	+0.191	+2.815	.017	.036	3	3
UCEC	Notch1 →	+0.213	+1.947	<.001	<.001	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.318	+1.935	.041	.002	3	2
UCEC	mTOR_pS2448 →	-0.129	-2.156	.004	.002	3	2
UCEC	PCNA →	+0.249	+1.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

MEK1 by ZC3H12C expression — UCEC

Explore this box plot interactively →