ZC3H12B

Across TCGA patient cohorts, ZC3H12B mutation is significantly associated with the RNA expression of many other genes, with 3,782 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H12B-associated genes across cancer lineages are LSS, TUBG1, and SKA3. Each is linked with ZC3H12B in more than 3 cancer types. Because this analysis shows association rather than direction, both ZC3H12B-to-partner and partner-to-ZC3H12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSS grouped by ZC3H12B-low versus ZC3H12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12B→partner) and Y-score (partner→ZC3H12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSS →	+0.324	+1.660	.003	.003	3	4
UCEC	TUBG1 →	+0.575	+1.799	<.001	<.001	3	4
UCEC	SKA3 →	+0.643	+1.809	<.001	<.001	3	3
UCEC	EI24 →	+0.393	+2.435	<.001	<.001	3	3
UCEC	NCAPD3 →	+0.536	+2.212	<.001	<.001	3	3
UCEC	CDC25C →	+0.384	+1.762	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,782 associations by consensus.

LSS by ZC3H12B expression — UCEC

Explore this box plot interactively →