ZC3H12A

Across TCGA pan-cancer cohorts, ZC3H12A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZC3H12A data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZC3H12A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3H12A expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where ZC3H12A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.333	0.725	.001	23	view →
PDAC	OS	Tertile	All	0.933	0.791	.004	22	view →
UCEC	OS	Median	III,IV	1.000	0.494	.016	16	view →
HNSC	OS	Median	IV	0.134	1.000	.008	11	view →
GBM	DFS	Median	All	0.669	0.820	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZC3H12A–CCRCC (DFS)

Open the CCRCC breakdown →