ZC3H12A

Across TCGA pan-cancer cohorts, ZC3H12A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ZC3H12A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZC3H12A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3H12A is over-expressed in tumor.

LUAD, PDAC, and CCRCC are the cancer types where ZC3H12A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H12A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.176	<.001	4	view →
PDAC	Female	III,IV	+0.815	.009	1	view →
CCRCC	All	II,III,IV	+0.186	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ZC3H12A–LUAD

Open the LUAD breakdown →