ZC3H11A

Across TCGA pan-cancer cohorts, ZC3H11A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZC3H11A data layer compared with 27 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZC3H11A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3H11A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where ZC3H11A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.083	0.908	.024	15	view →
UCEC	DFS	Median	All	0.944	0.866	.038	6	view →
LSCC	OS	Median	All	1.000	0.793	.025	3	view →
LUAD	DFS	Median	All	0.489	0.738	.042	2	view →
PDAC	OS	Median	II,III,IV	0.429	0.290	.037	2	view →
HNSC	DFS	Median	IV	0.749	0.555	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZC3H11A–CCRCC (DFS)

Open the CCRCC breakdown →