ZC2HC1C

Across TCGA pan-cancer cohorts, ZC2HC1C mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZC2HC1C’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ZC2HC1C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZC2HC1C is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

PDAC, LUAD, and COAD are the cancer types where ZC2HC1C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC2HC1C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−0.657	.002	4	view →
LUAD	All	All	+0.641	.003	4	view →
COAD	All	II,III,IV	+0.231	.025	4	view →
CCRCC	All	IV	−0.550	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZC2HC1C–PDAC

Open the PDAC breakdown →