ZC2HC1C

Across TCGA pan-cancer cohorts, ZC2HC1C RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZC2HC1C data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZC2HC1C RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZC2HC1C expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and KIRP are the cancer types where ZC2HC1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.748	0.518	<.001	108	view →
MESO	OS	Median	All	0.509	0.267	<.001	65	view →
KIRP	DFS	Median	All	0.946	0.565	<.001	47	view →
LGG	OS	Median	All	0.748	0.866	<.001	45	view →
BLCA	OS	Quartile	IV	0.277	0.615	<.001	44	view →
UVM	OS	Quartile	All	0.561	0.953	.005	34	view →
ACC	DFS	Quartile	IV	0.815	0.138	.006	30	view →
BRCA	OS	Median	All	0.955	0.894	<.001	29	view →
GBM	OS	Quartile	All	0.221	0.391	.002	25	view →
SARC	OS	Quartile	All	0.657	0.414	<.001	23	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →
PAAD	OS	Tertile	All	0.521	0.251	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZC2HC1C–KIRC (OS)

Open the KIRC breakdown →