ZC2HC1C

Across TCGA patient cohorts, ZC2HC1C mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC2HC1C-associated genes across cancer lineages are INPP4B, Notch1, and C-Raf. Each is linked with ZC2HC1C in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC2HC1C-to-partner and partner-to-ZC2HC1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ZC2HC1C-low versus ZC2HC1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC2HC1C→partner) and Y-score (partner→ZC2HC1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.305	-2.459	.022	.019	3	2
UCEC	Notch1 →	+0.132	+3.013	.023	.018	3	2
UCEC	C-Raf →	+0.167	+1.807	.004	.027	3	2
UCEC	EGFR_pY1068 →	-0.241	-3.169	.020	.019	3	1
UCEC	Heregulin →	-0.114	-2.000	.025	.030	3	1
UCEC	JNK2 →	+0.232	+1.807	.004	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

INPP4B by ZC2HC1C expression — UCEC

Explore this box plot interactively →