ZC2HC1C

Across TCGA cell cohorts, ZC2HC1C mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZC2HC1C-associated genes across cancer lineages are SOX14, KIR2DL3, and IFNG. Each is linked with ZC2HC1C in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC2HC1C-to-partner and partner-to-ZC2HC1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX14 grouped by ZC2HC1C-low versus ZC2HC1C-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC2HC1C→partner) and Y-score (partner→ZC2HC1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SOX14 →	+0.013	+4.977	<.001	.007	3	1
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
CNS	IFNG →	+0.081	+5.321	<.001	.005	3	1
OVARY	LCE6A →	+0.043	+5.807	<.001	.001	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SOX14 by ZC2HC1C expression — SKIN

Explore this box plot interactively →