ZC2HC1B

Across TCGA patient cohorts, ZC2HC1B mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC2HC1B-associated genes across cancer lineages are ZIC5, IGKV1OR2-118, and BNIP3P4. Each is linked with ZC2HC1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC2HC1B-to-partner and partner-to-ZC2HC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by ZC2HC1B-low versus ZC2HC1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC2HC1B→partner) and Y-score (partner→ZC2HC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZIC5 →	+1.964	+3.963	<.001	<.001	3	1
UCEC	IGKV1OR2-118 →	+0.256	+2.496	.003	.009	3	1
UCEC	BNIP3P4 →	+0.097	+3.262	<.001	.006	3	1
UCEC	RN7SL248P →	+0.127	+4.500	<.001	<.001	3	1
UCEC	RNVU1-28 →	+1.148	+2.857	<.001	.002	3	1
UCEC	RNF166 →	+0.721	+3.210	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

ZIC5 by ZC2HC1B expression — UCEC

Explore this box plot interactively →