ZBTB8B

Across TCGA patient cohorts, ZBTB8B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB8B-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with ZBTB8B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB8B-to-partner and partner-to-ZBTB8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZBTB8B-low versus ZBTB8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB8B→partner) and Y-score (partner→ZBTB8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.323	-3.584	.007	.002	3	1
UCEC	eIF4E →	+0.253	+3.584	.013	.002	3	1
UCEC	A-Raf_pS299 →	-0.158	-2.459	.006	.020	3	1
UCEC	Fibronectin →	-0.393	-3.156	.013	.018	3	1
UCEC	Heregulin →	-0.156	-2.459	.008	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.658	-3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by ZBTB8B expression — UCEC

Explore this box plot interactively →