ZBTB8B

Across TCGA pan-cancer cohorts, ZBTB8B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ZBTB8B data layer compared with 2 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ZBTB8B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB8B expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

LIHC, KIRC, and BRCA are the cancer types where ZBTB8B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.634	0.862	<.001	59	view →
KIRC	DFS	Tertile	II,III,IV	0.444	0.626	.003	46	view →
BRCA	DFS	Tertile	All	0.609	0.435	.003	42	view →
UCEC	OS	Tertile	All	0.645	0.808	.002	42	view →
UVM	OS	Median	II,III,IV	0.776	0.493	.009	31	view →
LUAD	DFS	Median	All	0.563	0.235	.005	26	view →
SCLC	DFS	Tertile	II,III,IV	1.000	0.228	.006	25	view →
OV	OS	Tertile	II,III,IV	0.346	0.275	.025	24	view →
LAML	DFS	Tertile	All	0.784	0.401	.001	24	view →
LGG	OS	Tertile	All	0.750	0.903	<.001	23	view →
LUSC	DFS	Quartile	III,IV	0.188	0.815	.004	21	view →
UCS	OS	Tertile	II,III,IV	0.699	0.254	.011	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ZBTB8B–LIHC (OS)

Open the LIHC breakdown →