ZBTB8A

Across TCGA patient cohorts, ZBTB8A mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB8A-associated genes across cancer lineages are EGFR_pY1068, FASN, and Notch1. Each is linked with ZBTB8A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB8A-to-partner and partner-to-ZBTB8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZBTB8A-low versus ZBTB8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB8A→partner) and Y-score (partner→ZBTB8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.273	-2.321	.008	.006	3	1
UCEC	FASN →	+0.408	+3.459	.012	.005	3	1
UCEC	Notch1 →	+0.159	+3.183	.006	.009	3	1
UCEC	p62 Lck ligand →	+0.437	+2.331	.001	.019	3	1
UCEC	PDCD4 →	-0.630	-2.321	.001	.006	3	1
UCEC	PKC-b-II_pS660 →	-0.245	-1.807	.032	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by ZBTB8A expression — UCEC

Explore this box plot interactively →