ZBTB8A

Across TCGA pan-cancer cohorts, ZBTB8A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZBTB8A data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZBTB8A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB8A expression acts as an unfavorable survival marker, although some lineages such as LUAD and THYM show a favorable association.

ACC, LUAD, and THYM are the cancer types where ZBTB8A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.376	0.832	<.001	128	view →
LUAD	OS	Tertile	II,III,IV	0.528	0.308	.001	43	view →
THYM	DFS	Tertile	II,III,IV	0.850	0.420	.001	42	view →
UCS	DFS	Median	II,III,IV	0.462	0.151	.007	28	view →
BRCA	DFS	Quartile	III,IV	0.930	0.758	.001	28	view →
LGG	DFS	Tertile	All	0.654	0.806	<.001	25	view →
SKCM	OS	Tertile	II,III,IV	0.882	0.770	.003	25	view →
LIHC	DFS	Quartile	All	0.379	0.559	.001	25	view →
GBM	DFS	Median	All	0.390	0.202	.005	18	view →
BLCA	DFS	Quartile	All	0.238	0.597	.006	16	view →
CHOL	OS	Tertile	All	1.000	0.191	.009	15	view →
CESC	DFS	Tertile	III,IV	0.147	0.767	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZBTB8A–ACC (OS)

Open the ACC breakdown →