ZBTB7B

Across TCGA patient cohorts, ZBTB7B mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB7B-associated genes across cancer lineages are eIF4E, S6_pS235_S236, and Ku80. Each is linked with ZBTB7B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB7B-to-partner and partner-to-ZBTB7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZBTB7B-low versus ZBTB7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB7B→partner) and Y-score (partner→ZBTB7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.172	+1.584	.014	.009	3	2
UCEC	S6_pS235_S236 →	+0.327	+1.678	.024	.021	3	2
UCEC	Ku80 →	+0.244	+1.598	.002	.006	3	1
UCEC	MEK1 →	+0.356	+2.321	.003	.005	3	1
UCEC	mTOR_pS2448 →	-0.104	-1.687	.037	.040	3	1
UCEC	Notch1 →	+0.125	+2.128	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by ZBTB7B expression — UCEC

Explore this box plot interactively →