ZBTB7B

Across TCGA pan-cancer cohorts, ZBTB7B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZBTB7B data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZBTB7B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZBTB7B expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

UVM, LGG, and MESO are the cancer types where ZBTB7B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.394	0.781	<.001	104	view →
LGG	DFS	Median	All	0.651	0.819	<.001	54	view →
MESO	OS	Median	All	0.503	0.282	.001	38	view →
KIRC	OS	Tertile	All	0.759	0.541	<.001	38	view →
KIRP	DFS	Median	All	0.874	0.954	.006	34	view →
HNSC	OS	Median	All	0.793	0.705	.002	29	view →
LUAD	OS	Quartile	All	0.738	0.840	.007	28	view →
LAML	DFS	Median	All	0.287	0.466	.015	18	view →
SARC	OS	Quartile	All	0.882	0.729	.006	13	view →
KICH	OS	Median	III,IV	0.357	0.907	.006	12	view →
LIHC	OS	Quartile	All	0.682	0.848	.011	12	view →
ACC	OS	Tertile	IV	1.000	0.329	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZBTB7B–UVM (OS)

Open the UVM breakdown →