ZBTB7B

Across TCGA cell cohorts, ZBTB7B mutation is significantly associated with the RNA expression of many other genes, with 530 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB7B-associated genes across cancer lineages are C17orf50, BANF2, and TNRC6B. Each is linked with ZBTB7B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB7B-to-partner and partner-to-ZBTB7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C17orf50 grouped by ZBTB7B-low versus ZBTB7B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB7B→partner) and Y-score (partner→ZBTB7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C17orf50 →	+0.042	+4.095	<.001	.009	3	2
BLOOD_Lymphoma	BANF2 →	+0.047	+5.643	<.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+0.885	+3.364	<.001	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.702	+3.364	<.001	.002	3	1
LARGE_INTESTINE	ZBED4 →	+0.617	+3.364	.001	.002	3	1
LARGE_INTESTINE	MED26 →	+0.332	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 530 associations by consensus.

C17orf50 by ZBTB7B expression — SKIN

Explore this box plot interactively →