ZBTB46

Across TCGA pan-cancer cohorts, ZBTB46 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZBTB46 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZBTB46 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZBTB46 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

UCEC, CCRCC, and GBM are the cancer types where ZBTB46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.565	0.956	.005	58	view →
CCRCC	DFS	Median	II,III,IV	0.800	0.253	.007	18	view →
GBM	OS	Median	All	0.677	0.180	.012	12	view →
LUAD	OS	Tertile	III,IV	0.429	0.879	.027	10	view →
HNSC	DFS	Median	All	0.339	0.880	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZBTB46–UCEC (DFS)

Open the UCEC breakdown →