ZBTB46

Across TCGA pan-cancer cohorts, ZBTB46 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZBTB46’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where ZBTB46 RNA is repressed in tumor relative to normal tissue. In most cancer types ZBTB46 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

UCEC, KICH, and STAD are the cancer types where ZBTB46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−1.832	<.001	8	view →
KICH	Female	III,IV	−1.503	<.001	8	view →
STAD	All	II,III,IV	+0.841	<.001	7	view →
KIRP	Male	All	−0.672	<.001	7	view →
HNSC	All	III,IV	+0.490	.001	7	view →
LUSC	Female	All	−1.022	<.001	6	view →
LIHC	Female	II,III,IV	+0.664	<.001	6	view →
LUAD	Female	All	−0.539	<.001	4	view →
COAD	All	II,III,IV	+0.229	.016	4	view →
BRCA	All	All	−0.206	.002	4	view →
CHOL	Female	All	+0.990	.003	2	view →
ESCA	All	All	+0.565	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZBTB46–UCEC

Open the UCEC breakdown →