ZBTB46

Across TCGA patient cohorts, ZBTB46 mutation is significantly associated with the RNA expression of many other genes, with 3,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB46-associated genes across cancer lineages are SPC25, BUB3, and SKA1. Each is linked with ZBTB46 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZBTB46-to-partner and partner-to-ZBTB46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC25 grouped by ZBTB46-low versus ZBTB46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB46→partner) and Y-score (partner→ZBTB46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC25 →	+0.531	+3.711	.005	<.001	3	3
UCEC	BUB3 →	+0.453	+2.577	<.001	<.001	3	3
UCEC	SKA1 →	+0.822	+4.108	<.001	<.001	3	3
UCEC	VPS37A →	+0.664	+3.233	<.001	<.001	3	3
UCEC	HSPA4L →	+0.973	+2.399	<.001	<.001	3	3
UCEC	SAP30 →	+0.451	+1.545	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,574 associations by consensus.

SPC25 by ZBTB46 expression — UCEC

Explore this box plot interactively →