ZBTB46

Across TCGA patient cohorts, ZBTB46 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB46-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and PDK1. Each is linked with ZBTB46 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZBTB46-to-partner and partner-to-ZBTB46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZBTB46-low versus ZBTB46-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB46→partner) and Y-score (partner→ZBTB46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.251	+1.593	.003	.043	3	4
COAD	Caspase-7-cleavedD198 →	+0.731	+3.186	.018	.009	3	3
SKCM	PDK1 →	+0.108	+3.169	.032	.018	3	2
UCEC	eEF2 →	+0.366	+3.321	.005	.009	3	2
UCEC	eIF4E →	+0.163	+1.502	.035	.030	3	2
UCEC	GSK-3_pS9 →	-0.300	-1.874	.043	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

4E-BP1 by ZBTB46 expression — COAD

Explore this box plot interactively →