ZBTB44-DT

Across TCGA pan-cancer cohorts, ZBTB44-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZBTB44-DT data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ZBTB44-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZBTB44-DT expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

UVM, UCS, and KIRC are the cancer types where ZBTB44-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.741	0.421	<.001	112	view →
UCS	OS	Median	IV	0.817	0.302	.002	70	view →
KIRC	OS	Tertile	All	0.714	0.545	<.001	32	view →
HNSC	OS	Median	IV	0.780	0.638	.003	31	view →
BLCA	OS	Quartile	II,III,IV	0.801	0.629	.004	30	view →
READ	DFS	Tertile	All	0.890	0.446	.001	29	view →
OV	DFS	Tertile	III,IV	0.606	0.509	.015	26	view →
LUAD	OS	Tertile	III,IV	0.845	0.428	.002	20	view →
GBM	OS	Quartile	All	0.285	0.602	.002	12	view →
DLBC	OS	Median	III,IV	0.272	1.000	.017	12	view →
SKCM	OS	Tertile	III,IV	0.708	0.880	.018	11	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.381	.040	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZBTB44-DT–UVM (DFS)

Open the UVM breakdown →