ZBTB44-DT

Across TCGA pan-cancer cohorts, ZBTB44-DT RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZBTB44-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZBTB44-DT RNA is repressed in tumor relative to normal tissue. In most cancer types ZBTB44-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where ZBTB44-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB44-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.542	<.001	11	view →
KICH	Male	All	−1.175	<.001	8	view →
BRCA	Female	II,III,IV	−0.403	<.001	6	view →
LUSC	All	All	−0.225	<.001	5	view →
KIRP	Male	All	−0.435	.005	4	view →
KIRC	All	All	−0.234	<.001	4	view →
PRAD	All	All	+0.129	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZBTB44-DT–THCA

Open the THCA breakdown →