ZBTB43

Across TCGA patient cohorts, ZBTB43 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB43-associated genes across cancer lineages are FASN, EGFR_pY1068, and MEK1. Each is linked with ZBTB43 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB43-to-partner and partner-to-ZBTB43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ZBTB43-low versus ZBTB43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB43→partner) and Y-score (partner→ZBTB43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.253	+1.847	.036	.007	3	3
COAD	EGFR_pY1068 →	-0.399	-3.000	.013	.034	3	2
UCEC	MEK1 →	+0.452	+1.947	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.103	-1.420	.023	.022	3	2
UCEC	Notch1 →	+0.122	+1.263	.004	.019	3	2
UCEC	Shc_pY317 →	-0.160	-1.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FASN by ZBTB43 expression — UCEC

Explore this box plot interactively →