ZBTB43

Across TCGA pan-cancer cohorts, ZBTB43 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZBTB43’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZBTB43 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB43 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where ZBTB43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.476	<.001	7	view →
KIRP	All	IV	+0.757	.033	6	view →
KIRC	Male	II,III,IV	−0.340	.002	5	view →
KICH	All	All	+0.466	.001	4	view →
CHOL	All	All	+0.776	.016	2	view →
BLCA	Male	III,IV	+0.384	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZBTB43–HNSC

Open the HNSC breakdown →