ZBTB43

Across TCGA cell cohorts, ZBTB43 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB43-associated genes across cancer lineages are CUEDC2, ALDH6A1, and PPP2R5E. Each is linked with ZBTB43 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB43-to-partner and partner-to-ZBTB43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUEDC2 grouped by ZBTB43-low versus ZBTB43-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB43→partner) and Y-score (partner→ZBTB43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUEDC2 →	+0.767	+3.064	<.001	.009	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.105	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PPP2R5E →	+0.619	+3.169	.001	.005	3	1
LARGE_INTESTINE	SKA1 →	+0.866	+3.067	.004	.009	3	1
LARGE_INTESTINE	ING2 →	+0.521	+3.067	.007	.009	3	1
LARGE_INTESTINE	PDIK1L →	+0.751	+3.082	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CUEDC2 by ZBTB43 expression — LARGE_INTESTINE

Explore this box plot interactively →