ZBTB42

Across TCGA patient cohorts, ZBTB42 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB42-associated genes across cancer lineages are EGFR_pY1068, ASNS, and 4E-BP1. Each is linked with ZBTB42 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB42-to-partner and partner-to-ZBTB42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZBTB42-low versus ZBTB42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB42→partner) and Y-score (partner→ZBTB42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.315	-2.807	.004	.003	3	2
UCEC	ASNS →	+0.330	+2.321	.036	.034	3	2
UCEC	4E-BP1 →	+0.419	+3.489	<.001	.002	3	2
COAD	Smad4 →	+0.248	+3.178	<.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.186	-3.321	<.001	.010	3	1
UCEC	ERK2 →	+0.205	+2.807	.015	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by ZBTB42 expression — UCEC

Explore this box plot interactively →