ZBTB42

Across TCGA pan-cancer cohorts, ZBTB42 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZBTB42’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZBTB42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB42 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LIHC, LUAD, and BRCA are the cancer types where ZBTB42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.937	<.001	9	view →
LUAD	Female	II,III,IV	−0.520	.002	7	view →
BRCA	All	All	+0.733	<.001	6	view →
CHOL	All	All	+1.236	<.001	5	view →
STAD	Male	All	+0.514	.001	4	view →
KIRP	All	All	−0.394	.007	3	view →
LUSC	All	All	−0.392	.005	3	view →
KIRC	All	All	+0.390	<.001	3	view →
COAD	All	All	+0.282	.006	3	view →
PRAD	All	All	+0.624	<.001	2	view →
KICH	Male	All	−0.588	.041	2	view →
THCA	All	All	+0.215	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZBTB42–LIHC

Open the LIHC breakdown →