ZBTB40-IT1

Across TCGA pan-cancer cohorts, ZBTB40-IT1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZBTB40-IT1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZBTB40-IT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZBTB40-IT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

LUAD, ACC, and COAD are the cancer types where ZBTB40-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.876	0.709	.002	65	view →
ACC	OS	Median	All	0.289	0.843	<.001	59	view →
COAD	DFS	Median	All	0.374	0.630	<.001	49	view →
BRCA	DFS	Tertile	III,IV	0.650	0.422	.002	48	view →
STAD	DFS	Tertile	II,III,IV	0.410	0.642	<.001	47	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LGG	DFS	Tertile	All	0.668	0.817	<.001	34	view →
UVM	DFS	Quartile	III,IV	0.229	0.710	.012	26	view →
SKCM	OS	Quartile	III,IV	0.652	0.290	<.001	22	view →
READ	OS	Median	III,IV	0.724	0.269	.001	20	view →
KIRC	DFS	Median	III,IV	0.817	0.660	.022	16	view →
CESC	DFS	Quartile	III,IV	0.217	0.709	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZBTB40-IT1–LUAD (OS)

Open the LUAD breakdown →