ZBTB40-IT1

Across TCGA pan-cancer cohorts, ZBTB40-IT1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZBTB40-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZBTB40-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB40-IT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where ZBTB40-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB40-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.305	<.001	8	view →
HNSC	All	II,III,IV	+0.189	.003	6	view →
COAD	All	II,III,IV	+0.336	.002	5	view →
LIHC	All	All	+0.130	<.001	3	view →
BLCA	Female	IV	+0.803	.049	1	view →
THCA	Female	II,III,IV	−0.369	.043	1	view →
LUAD	All	All	+0.289	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZBTB40-IT1–KIRC

Open the KIRC breakdown →