ZBTB4

Across TCGA cell cohorts, ZBTB4 mutation is significantly associated with the RNA expression of many other genes, with 596 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB4-associated genes across cancer lineages are OR56A5, UBE2D3, and FAM149A. Each is linked with ZBTB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB4-to-partner and partner-to-ZBTB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by ZBTB4-low versus ZBTB4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB4→partner) and Y-score (partner→ZBTB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	2
LARGE_INTESTINE	UBE2D3 →	+0.437	+2.628	.004	.002	3	2
LARGE_INTESTINE	FAM149A →	+1.253	+2.628	<.001	.002	3	2
LARGE_INTESTINE	RIC8B →	+0.453	+2.628	.005	.002	3	2
LARGE_INTESTINE	IFT43 →	+0.640	+3.829	<.001	<.001	3	2
LARGE_INTESTINE	FXR2 →	+0.488	+3.169	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 596 associations by consensus.

OR56A5 by ZBTB4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →