ZBTB39

Across TCGA patient cohorts, ZBTB39 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB39-associated genes across cancer lineages are AR, 14-3-3_beta, and EGFR_pY1068. Each is linked with ZBTB39 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB39-to-partner and partner-to-ZBTB39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by ZBTB39-low versus ZBTB39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB39→partner) and Y-score (partner→ZBTB39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AR →	-0.261	-1.152	.020	.048	3	2
UCEC	14-3-3_beta →	-0.094	-4.060	.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.247	-1.999	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.130	-2.392	<.001	<.001	3	1
UCEC	FoxM1 →	+0.184	+1.425	.018	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.097	-1.238	.010	.041	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

AR by ZBTB39 expression — UCEC

Explore this box plot interactively →