ZBTB39

Across TCGA pan-cancer cohorts, ZBTB39 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZBTB39’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZBTB39 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB39 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where ZBTB39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.724	<.001	11	view →
COAD	Male	All	+0.812	<.001	10	view →
BLCA	All	All	+0.669	<.001	8	view →
LUSC	Male	II,III,IV	+0.974	<.001	7	view →
LIHC	Male	All	+0.610	<.001	7	view →
CHOL	Male	All	+1.375	<.001	5	view →
STAD	All	II,III,IV	+0.819	<.001	4	view →
THCA	All	II,III,IV	−0.433	.006	4	view →
READ	All	All	+0.678	.012	2	view →
LUAD	Male	All	+0.437	.019	2	view →
PRAD	All	All	+0.398	<.001	2	view →
ESCA	All	All	+0.461	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZBTB39–HNSC

Open the HNSC breakdown →