ZBTB39

Across TCGA cell cohorts, ZBTB39 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB39-associated genes across cancer lineages are PFN3, AVP, and SEMG2. Each is linked with ZBTB39 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB39-to-partner and partner-to-ZBTB39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by ZBTB39-low versus ZBTB39-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB39→partner) and Y-score (partner→ZBTB39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PFN3 →	+0.105	+3.297	<.001	.002	3	2
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	SEMG2 →	+0.588	+2.878	<.001	.009	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FANCD2OS →	+0.178	+3.667	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PFN3 by ZBTB39 expression — LARGE_INTESTINE

Explore this box plot interactively →