ZBTB34

Across TCGA patient cohorts, ZBTB34 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB34-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-7-cleavedD198, and ATM. Each is linked with ZBTB34 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB34-to-partner and partner-to-ZBTB34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ZBTB34-low versus ZBTB34-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB34→partner) and Y-score (partner→ZBTB34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JNK_pT183_Y185 →	-0.285	-3.459	.008	.005	3	3
COAD	Caspase-7-cleavedD198 →	+1.181	+2.593	<.001	.006	3	3
UCEC	ATM →	-0.528	-1.836	<.001	.001	3	3
COAD	FASN →	+0.673	+1.882	<.001	.031	3	2
COAD	STAT3_pY705 →	-0.272	-2.576	.012	.011	3	2
COAD	ASNS →	+0.673	+2.593	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

JNK_pT183_Y185 by ZBTB34 expression — COAD

Explore this box plot interactively →