ZBTB34

Across TCGA pan-cancer cohorts, ZBTB34 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZBTB34’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZBTB34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB34 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where ZBTB34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.779	<.001	12	view →
BLCA	All	All	+0.585	.002	8	view →
LIHC	Female	II,III,IV	+0.860	<.001	7	view →
KIRP	All	IV	+0.974	.011	6	view →
LUAD	Female	II,III,IV	−0.572	<.001	6	view →
CHOL	All	II,III,IV	+2.094	<.001	5	view →
STAD	All	II,III,IV	+0.517	.008	4	view →
BRCA	Female	All	−0.217	.001	4	view →
KICH	All	All	−0.470	.001	3	view →
ESCA	All	All	+0.606	.033	2	view →
UCEC	All	All	−0.435	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZBTB34–HNSC

Open the HNSC breakdown →