ZBTB34

Across TCGA cell cohorts, ZBTB34 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZBTB34-associated genes across cancer lineages are PZP, USP17L4, and MMP26. Each is linked with ZBTB34 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB34-to-partner and partner-to-ZBTB34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PZP grouped by ZBTB34-low versus ZBTB34-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB34→partner) and Y-score (partner→ZBTB34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PZP →	+0.036	+4.807	<.001	.006	3	1
BLOOD_Myeloma	USP17L4 →	+0.040	+4.807	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.010	+3.217	.002	.006	3	1
LARGE_INTESTINE	SMIM33 →	+0.464	+3.426	.007	.007	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PZP by ZBTB34 expression — BLOOD_Myeloma

Explore this box plot interactively →