Across TCGA patient cohorts, ZBTB3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB3-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Ku80. Each is linked with ZBTB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB3-to-partner and partner-to-ZBTB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB3→partner) and Y-score (partner→ZBTB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.328	-3.169	.006	.019	3	1
UCEC	JNK2 →	+0.346	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.296	+2.472	.009	.011	3	1
UCEC	p62 Lck ligand →	+0.580	+3.584	<.001	.002	3	1
UCEC	PDK1_pS241 →	+0.169	+3.169	.040	.019	3	1
UCEC	Tuberin →	+0.402	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

ZBTB3 survival (RNA) · tumor vs normal (RNA) · all ZBTB3 data types