Across TCGA pan-cancer cohorts, ZBTB3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZBTB3’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZBTB3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.
LIHC, THCA, and CHOL are the cancer types where ZBTB3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.