ZBTB26

Across TCGA patient cohorts, ZBTB26 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB26-associated genes across cancer lineages are MEK1, p62 Lck ligand, and CDK1. Each is linked with ZBTB26 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB26-to-partner and partner-to-ZBTB26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZBTB26-low versus ZBTB26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB26→partner) and Y-score (partner→ZBTB26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.440	+3.584	.003	.002	3	2
UCEC	p62 Lck ligand →	+0.376	+3.469	.005	.002	3	2
UCEC	CDK1 →	+0.149	+1.807	.016	.027	3	2
UCEC	EGFR_pY1068 →	-0.270	-1.807	.009	.027	3	1
UCEC	eIF4E →	+0.175	+2.321	.045	.034	3	1
UCEC	Myosin-IIa →	+0.184	+2.229	.019	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by ZBTB26 expression — UCEC

Explore this box plot interactively →