ZBTB26

Across TCGA pan-cancer cohorts, ZBTB26 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZBTB26’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZBTB26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZBTB26 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where ZBTB26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.637	<.001	11	view →
THCA	Male	III,IV	−0.881	<.001	9	view →
LIHC	Female	II,III,IV	+0.954	<.001	8	view →
CHOL	All	All	+2.019	<.001	5	view →
UCEC	All	All	−0.907	<.001	2	view →
KICH	All	All	−0.575	.004	2	view →
LUSC	All	All	+0.325	.008	2	view →
BLCA	Male	IV	−0.847	.021	1	view →
ESCA	All	All	+0.591	.030	1	view →
LUAD	Female	III,IV	−0.418	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZBTB26–HNSC

Open the HNSC breakdown →